Monday , January 30 2023

Sinequan (Doxepin)

Generic Name: Doxepin (DOX-e-pin)

Brand Names: Sinequan



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Sinequan is a brand name for orally consumable Doxepin, which is a tricyclic antidepressant. Sinequan is available in 10, 25, 50, 75 and 100 milligram capsules. Sinequan is a prescription-only medication used to treat mainly clinical depression and anxiety.


Drug Information


Sinequan’s active ingredient is Doxepin, a drug that belongs to a class of chemical compounds called tricyclic antidepressants. Doxepin can affect the balance of neurotransmitters in the brain, and help to manage a range of mood disorders. Sinequan is available in hard gelatinous capsules, color coded for different dosages.


Sinequan is an approved medication to treat depression, anxiety, manic-depression, insomnia, and in some cases alcoholism and mood-affecting psychiatric conditions. Doxepin was also used in the past to treat Attention Deficit Hyperactive disorder (ADHD), but has been replaced by newer medications specifically targeting the condition.




Sinequan should only be taken as directed by a physiatrist or a physician. Swallow the oral capsules as instructed on time each day. Continue treatment without pause or missing doses for the drug to be effective.


Strictly adhere to the dosage limits as prescribed. Doxepin, the active ingredient in Sinequan, is highly toxic in higher doses. Mild symptoms of Doxepin overdose include unusually dry mouth, dilated pupils, drowsiness, blurred vision, urinary retention, hyperactive reflexes and stupor.


Severe symptoms of Doxepin overdose can include convulsions, respiratory depression, hypotension, hypertension, tachycardia, cardiac arrhythmia, and even coma. Immediately seek emergency medical treatment if a Doxepin overdose is suspected.




There is significant research to suggest that antidepressants, like Sinequan, increase the risk of suicidal thought and behavior in children, adolescents and young adults suffering from major depression and similar psychiatric disorders. Therefore, Sinequan is not approved for pediatric prescription.


Antidepressants are considered safer in comparison for use with young adults over the age of 24. However, family members and caregivers are advised to remain vigilant regarding patients who begin antidepressant treatments.


Side Effects


The following side effects are known to be associated with Sinequan treatments:


four_dot_bullet_red Dry mouth
four_dot_bullet_red Blurred vision
four_dot_bullet_red Dizziness or lightheadedness
four_dot_bullet_red Drowsiness
four_dot_bullet_red Constipation
four_dot_bullet_red Trouble urinating


The side effects are easily manageable. Chew on popsicles or gum to reduce dry mouth. Drink plenty of liquids to ease urination. Consume a diet rich in fiber to relieve constipation. Be careful when getting up or lying down to reduce dizziness. Consult a physician if any of the side effects worsen over time.


Severe side effects from Sinequan is rare but could include heartburn, debilitating stomach pain or mood swings. Consult a physician immediately if such side effects occur.




four_dot_bullet_red Do not take Sinequan if allergic to Doxepin or other tricyclic antidepressants.


four_dot_bullet_red Do not take tricyclic antidepressants if pregnant or suspected to be pregnant without explicit instructions from a physician. Sinequan can pass through breast milk to an infant so the drug is not recommended for breastfeeding mothers.


four_dot_bullet_red Do not drive if Sinequan causes side effects such as blurred vision or dizziness.


Sinequan is not recommended for patients with a history of heart problems, liver problems, glaucoma, urinary problems, seizures, breathing problems, bleeding problems or mood disorders such as bipolar disorder or psychosis.


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