Monday , January 30 2023

Pamelor (Nortriptyline)

Generic Name: Nortriptyline (nor TRIP ti leen)

Brand Names: Pamelor



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Pamelor is a brand name for nortriptyline HCL, an antidepressant used to treat mood disorders such as clinical depression. Pamelor is sometimes used to treat childhood enuresis, chronic fatigue syndrome and migraines.


Pamelor is available in a pill form for oral consumption.


Drug Information


The active ingredient in Pamelor is a tricyclic antidepressant called nortriptyline HCL. Nortriptyline can affect the balance of neurotransmitters like serotonin and dopamine in the brain, thus relieving symptoms of psychiatric mood disorders and depression. Nortriptyline HCL is particularly effective against endogenous depression, which is characterised by abnormal behavior in the endogenous opioids produced by the body.


Nortriptyline HCL is sometimes prescribed to treat childhood bedwetting (enuresis), panic disorders, and rarely, chronic fatigue syndrome and migraines, if other medications do not work.


Pamelor is mainly prescribed for patients with depression.






Pamelor is available mainly in capsule form that patients should swallow. Dosage depends on as prescribed by a healthcare practitioner.


Carefully read all instructions in the patient information leaflet that comes with the package before using. Ask a healthcare practitioner or a pharmacist if any of the instructions are not clear.


Do not take Pamelor more or less than directed. More could result in an overdose, and less would not be effective against the medical condition.


Black Label Warning


Pamelor, as with similar tricyclic antidepressants, comes with a black label warning against increased risk of suicide in users.


Tricyclic antidepressants like Pamelor can increase the risk of suicidal behavior and thought in children, teens and young adults. Therefore, caregivers should pay close attention to mood swings and unusual behavior in patients who begin Pamelor treatments.


Pamelor is not prescribed for children under 12 years due to safety concerns.


Side Effects


Following side effects can occur when undergoing nortriptyline HCL treatment:


four_dot_bullet_red Fainting feeling
four_dot_bullet_red Dry mouth
four_dot_bullet_red Chest pain and fluttering heartbeat
four_dot_bullet_red Numbness
four_dot_bullet_red Dizziness
four_dot_bullet_red Blurred vision
four_dot_bullet_red Fever or sore throat
four_dot_bullet_red Restless muscles
four_dot_bullet_red Painful urination
four_dot_bullet_red Convulsions
four_dot_bullet_red Abdominal pain
four_dot_bullet_red Nausea
four_dot_bullet_red Constipation
four_dot_bullet_red Ringing in ears
four_dot_bullet_red Decreased sex drive and possible impotence
four_dot_bullet_red Jaundice (yellowing of skin and eyes)
four_dot_bullet_red Lack of coordination in limbs
four_dot_bullet_red Feeling weak
four_dot_bullet_red Loss of appetite


Possibly severe side effects experienced with tricyclic antidepressants not limited to Pamelor:


four_dot_bullet_red Hypertension
four_dot_bullet_red Hypotension
four_dot_bullet_red Hallucinations
four_dot_bullet_red Exacerbation of psychosis or depression
four_dot_bullet_red Stroke
four_dot_bullet_red Myocardial infarction


Seek immediate medical care if side effects continue to persist or worsen over time.




Nortriptyline HCL can dangerously interact with Monoamine Oxidase Inhibitors (MAOIs) such as linezolid, selegiline, methylene blue, isocarboxazid, phenelzine and rasagiline. It’s recommend to wait at least 14 days in between these drugs to avoid a life-threatening condition called Serotonin Syndrome.


four_dot_bullet_red Do not take Pamelor if allergic to nortriptyline HCL or other tricyclic antidepressants.


four_dot_bullet_red Do not take Pamelor if pregnant, breastfeeding or suspected to be pregnant without explicit instructions from a physician.


four_dot_bullet_red Do not drive if Pamelor causes side effects such as blurred vision or dizziness.


Patients with a history of heart conditions, liver problems, breathing problems, bleeding problems or mood disorders such as bipolar disorder or psychosis, should disclose such facts to a healthcare practitioner before taking Pamelor.


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